CanAg Diagnostics (Beijing) Co., Ltd.
Room 1151, Hotel Nikko New Century Beijing Office Tower Building,
No.6 Southern Road Capital Gym, Haidian District, Beijing, China
Post code: 100044
Tel: +86 10 8528 8156 68492672
Fax: +86 10 8528 8382
Tel: +86 10 88431258/2778/2621
Fax: +86 10 88434018
The INNOTEST β-AMYLOID(1-42) is a solid-phase enzyme immunoassay for the quantitative determination of β-amyloid(1-42) in human cerebrospinal fluid (CSF). This assay is designed to detect the amyloid peptide called Aβ resulting from β-secretase
way of APP (amyloid precursor protein) maturation and starting at the 1st amino acid (AA) of N-terminal extremity and finishing at position 42. This peptide, hydrophobic and neurotoxic, is a major component of amyloid deposits.
The combined use of CSF-β-amyloid(1-42) and CSF-TAU marker concentrations allows differentiation between Alzheimer's disease (AD) and normal aging or other neurological diseases such as depression . As AD diagnosis marker, the results obtained with this assay should be interpreted in combination with other clinical and diagnostic information (eg, using results obtained with the INNOTEST hTAU Ag and the INNOTEST PHOSPHO-TAU(181P)). The discrimination of AD from non-AD types of dementia such as dementia with Lewy Bodies may further be improved using the quantification of CSF-Phospho-TAU181 .